Unique panel of 3 aberrantly glycosylated proteins relevant to progression
Glycosylation = carbohydrate-associated post-translational modifications = tumour cell signature
Alterations in glycosylation directly impact cell growth and survival and modulate tumour-induced immunomodulation and eventual metastasis.
PSA is a glycoprotein - elevated in non-cancerous conditions also (diagnostic grey zone 4-10ng = 25% chance of PC)
Funding needed to conduct a 12 month study to determine whether the test is able to predict high vs low grade prostate cancer